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ChemicalBook >> CAS DataBase List >>L-5-Hydroxytryptophan


Chemical Name:
5-HTP;OXITRIPTAN;(S)-2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid;L-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID;L-5-HTP;Griffonia seed;5-hydroxy-l-tryptopha;5-Hydroxy-L-tryptophane;L-HTP;quietim
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
MSDS File:
Last updated:2024-10-26 18:06:12

L-5-Hydroxytryptophan Properties

Melting point 270 °C (dec.) (lit.)
alpha -32.5 º (c=1,H2O on dry basis)
Boiling point 361.16°C (rough estimate)
Density 0.902 g/mL at 25 °C (lit.)
refractive index n20/D 1.4850(lit.)
Flash point 175 °F
storage temp. 2-8°C
solubility H2O: 10 mg/mL
pka 2.22±0.10(Predicted)
form solid
color white
optical activity [α]22/D 30°, c = 1 in H2O
Water Solubility Slightly soluble
Merck 14,4847
BRN 88200
LogP -0.140 (est)
CAS DataBase Reference 4350-09-8(CAS DataBase Reference)
NCI Drug Dictionary
ATC code
EPA Substance Registry System


Risk and Safety Statements

Symbol(GHS)  trực tiếp đá gà hôm nayLiên kết đăng nhập
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P330+P331+P310
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38-65-20/21/22-20/21
Safety Statements  36-26
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  YN7110000
HazardClass  6.1
PackingGroup  III
HS Code  29339990
NFPA 704
2 0

L-5-Hydroxytryptophan price More Price(58)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHL80477 5-Hydroxy-L-tryptophan phyproof? Reference Substance 4350-09-8 50MG $250 2024-06-20 Buy
Sigma-Aldrich 107751 5-Hydroxy-L-tryptophan 98% (calc. on dried substance) 4350-09-8 1g $42.7 2024-06-20 Buy
Sigma-Aldrich PHR2597 5-Hydroxy-L-tryptophan Pharmaceutical Secondary Standard; Certified Reference Material 4350-09-8 100MG $233 2023-05-15 Buy
Sigma-Aldrich 399698 5-Hydroxy-L-tryptophan - CAS 895096 - Calbiochem Serotonin precursor. 4350-09-8 25G $466 2023-05-15 Buy
Sigma-Aldrich 1329913 5-Hydroxy-L-tryptophan United States Pharmacopeia (USP) Reference Standard 4350-09-8 100mg $400 2023-05-15 Buy
Product number Packaging Price Buy
PHL80477 50MG $250 Buy
107751 1g $42.7 Buy
PHR2597 100MG $233 Buy
399698 25G $466 Buy
1329913 100mg $400 Buy

L-5-Hydroxytryptophan Chemical Properties,Uses,Production

Chemical Properties

white to pale grey powder


5-Hydroxy-L-Tryptophan is a hydroxylated metabolite of L-Tryptophan


A labelled metabolite of Tryptophan


5-Hydroxy-L-tryptophan has been used:

  • to inject experimental mice for serotonin detection
  • as a precursor of 5-hydroxytryptamine and injected in pregnant mice and neonatal rats for vital neutral red staining of lung slices
  • as a standard in citrate-acetate buffer for its use in high performance liquid chromatography (HPLC) analysis


ChEBI: 5-hydroxy-L-tryptophan is the L-enantiomer of 5-hydroxytryptophan. It has a role as a human metabolite, a plant metabolite and a mouse metabolite. It is a 5-hydroxytryptophan, a hydroxy-L-tryptophan and a non-proteinogenic L-alpha-amino acid. It is an enantiomer of a 5-hydroxy-D-tryptophan. It is a tautomer of a 5-hydroxy-L-tryptophan zwitterion.

General Description

Colorless to pale pink crystals.

Air & Water Reactions

L-5-Hydroxytryptophan is sensitive to air. Slightly water soluble .

Reactivity Profile

L-5-Hydroxytryptophan reacts with bases. .

Fire Hazard

Flash point data for L-5-Hydroxytryptophan are not available, however, L-5-Hydroxytryptophan is probably combustible.

Trade name

Levothym (Promonta Lundbeck, Germany), Lévotonine (Panpharma, France), Oxyfan (Coli, Italy), Tript-OH (Sigma- Tai, Italy).

Biochem/physiol Actions

Hydroxylation of L-tryptophan occurs in the brain during serotonin synthesis. This is a step that controls the production of serotonin and also yields 5-hydroxy-l-tryptophan (5-HTP) as a metabolite. Thus, consumption 5-HTP, increases the serotonin level, which might result in depression, lack of sleep and severe headache.

Purification Methods

Likely impurities are 5-hydroxy-D-tryptophan and 5-benzyloxytryptophan. Crystallise 5-hydroxy-L-tryptophan under nitrogen from water by adding EtOH. Store it under nitrogen. Also dissolve it in the minimum volume of hot H2O (~0.7g in 4mL) under nitrogen (charcoal) and allowed it to crystallise at 5o. The picrolonate crystallises from H2O with m 184-186o(dec). [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2732-2737 1961, Morris & Armstrong J Org Chem 22 306 1957, Beilstein 22/14 V 278.]
Synthesis of L-5-Hydroxytryptophan from 1H-Indole-3-propanamide, α-amino-5-hydroxy-, (αS)-

L-5-Hydroxytryptophan Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 444)Suppliers
Supplier Tel Email Country ProdList Advantage
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd.
+undefined13970866816 China 246 58
15202951039 China 268 58
Shanghai UCHEM Inc.
+862156762820 +86-13564624040 China 6419 58
+8618058761490 China 50001 58
Hebei Mojin Biotechnology Co., Ltd
15028179902 +8615028179902 China 12367 58
Firsky International Trade (Wuhan) Co., Ltd
+8615387054039 China 436 58
Hebei Fengqiang Trading Co., LTD
+8613373049370 China 981 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 China 14666 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 China 21709 55

View Lastest Price from L-5-Hydroxytryptophan manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
trực tiếp đá gà hôm nayLiên kết đăng nhập 2025-01-26 L-5-Hydroxytryptophan
US $1.00 / ASSAYS 1g 99.99%+ 20T Jinan Jianfeng Chemical Co., Ltd
trực tiếp đá gà hôm nayLiên kết đăng nhập 2024-12-19 L-5-Hydroxytryptophan
US $18.00-206.00 / g 25g 0.99 100kg Shanghai UCHEM Inc.
trực tiếp đá gà hôm nayLiên kết đăng nhập 2024-10-08 L-5-Hydroxytryptophan
US $30.00 / KG 1KG 99% 20T Firsky International Trade (Wuhan) Co., Ltd
L-5-HYDROXYTRYPTOPHAN HYDRATE L-5-HYDROXYTRYPTOPHAN 2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)PROPIONIC ACID (-)-5-HYDROXY-L-TRYPTOPHAN 5-HYDROXY-L-TRP-OH pretonine L-5-Hydroxytryptophan, 99% 5GR L-5-HTP, L-2-Amino-3-(5-hydroxyindolyl)propionic acid 5-Hydroxy-L-tryphophane 5-Hydroxy-L-tryptophan 98% (calc. on dried substance) 5-Hydroxy-L-tryptophan(5-HTP) 5-Hydroxy-L-tryptophan99% L-Trp(5-OH)-OH 5-Hydroxy-L-tryptophan, Free Acid L-Tryptophan, 5-hydroxy- l-2-amino-3-[3-(5-hydroxyindole)]propionic acid 5-HYDROXY-1-TRYTOPHAN 5-Hydroxyl-L-tryptophan. quietim 5-HYDROXY-L-TRYPTOPHAN 99,0 % min H-L-Trp(5-OH)-OH 5-HTP Griffonia Seed L-2-Amino-3-(5-hydroxyindolyl)propionic acid, L-5-HTP 5-HYDROXY-L-TRYPTOPHAN 99% 5-HTP HPLC L-2-Amino-3-(5-hydroxyindolyl)propionic acid L-5-HTP 5-HTP 5-Hydroxy-L-tryptophan, Dihydrate 5-HYDROXY-TRP-OH C5-HYDROXY-L-TRYPTOPHAN H-5-HYDROXY-TRP-OH H-TRP(5-OH)-OH (S)-2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)-PROPIONIC ACID (2S)-2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid Levothym L-5-Hydroxytryptophan,99% L-5-Hydroxytryptopha (S)-5-Hydroxytryptophan 5-Hydroxytryptophan(5-HTP,Oxitriptan) (S)-2-AMino-3-(5-hydroxy-1H-indol-3-yl)-propionic acid, C5-Hydroxy-L-tryptophan, 5-HTP, Oxitriptan 5-Hydroxy-L-tryptophan-d 3 L-5-Hydroxytryptophan, 99% 1GR L-oxitriptan L-5-Hydroxytryptophan USP/EP/BP N-Acetyltryptophan EP Impurity D laevo-oxitriptan 5-Hydroxy L-trpytophan, 99% TIANFU-CHEM CAS NO.4350-09-8 Polyurethane foams 5-Hydroxy-L-Tryptophan extrapure, 99% 5-Hydroxy-L-tryptophan (1329913) L-HTP Tryptophan Impurity 9(Tryptophan EP Impurity D) L-5-Hydroxytryptophan (Synonyms: L-5-HTP Ghana seed extract L-5-Hydroxytryptophan (L-5-HTP L-5-Hydroxytryptophan(Tryptophan EP Impurity D) HPLC>=98% 5-Hydroxy-L-tryptophan> (S)-2-Amino-3-(5-hydroxy-1H-indol-3 L-5-HTP
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