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ChemicalBook >> CAS DataBase List >>6-Chloroguanine

6-Chloroguanine

CAS No.
10310-21-1
Chemical Name:
6-Chloroguanine
Synonyms
2-AMINO-6-CHLOROPURINE;6-Chloro-7H-purin-2-amine;2-amino-6-chloro-purin;6-CHLORO-2-AMINOPURINE;9H-PURIN-2-AMINE, 6-CHLORO-;2-AMINO-6-CHLOROPURINE (2A6ClP);AURORA KA-689;6-CHLOROGUANINE;TIMTEC-BB SBB003863;2-AMino-6-chlorpurin
CBNumber:
CB4143631
Molecular Formula:
C5H4ClN5
Molecular Weight:
169.57
MDL Number:
MFCD00075252
MOL File:
10310-21-1.mol
MSDS File:
SDS
Last updated:2024-08-01 14:32:22

6-Chloroguanine Properties

Melting point >300 °C (lit.)
Boiling point 279.76°C (rough estimate)
Density 1.4937 (rough estimate)
refractive index 1.6110 (estimate)
storage temp. 2-8°C
solubility Solubility in 1mol/L NaOH
form Powder
pka 6.65±0.20(Predicted)
color White to yellow
Water Solubility 1.7 g/L (20 ºC)
BRN 9626
InChI InChI=1S/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11)
InChIKey RYYIULNRIVUMTQ-UHFFFAOYSA-N
SMILES N1C2C(=NC(N)=NC=2Cl)NC=1
CAS DataBase Reference 10310-21-1(CAS DataBase Reference)
EWG's Food Scores
FDA UNII
EPA Substance Registry System

SAFETY

Risk and Safety Statements

Symbol(GHS)  trực tiếp đá gà hôm nayLiên kết đăng nhập
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P201-P202-P261-P264b-P271-P280i-P302+P352-P304+P340-P305+P351+P338-P308+P313-P332+P313-P362+P364-P403+P233-P501c
Hazard Codes  Xi,Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  22-24/25-36-26
WGK Germany  3
RTECS  UO7502000
10
Hazard Note  Irritant/Keep Cold
HazardClass  IRRITANT, KEEP COLD
HS Code  29339900
NFPA 704
1
2 0

6-Chloroguanine price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 109789 2-Amino-6-chloropurine ≥99% 10310-21-1 1g $25 2024-06-20 Buy
Sigma-Aldrich 109789 2-Amino-6-chloropurine ≥99% 10310-21-1 5g $50 2024-06-20 Buy
Sigma-Aldrich PHR2861 Famciclovir Related Compound F pharmaceutical secondary standard, certified reference material 10310-21-1 50MG $424 2023-05-15 Buy
TCI Chemical A1407 2-Amino-6-chloropurine >98.0%(HPLC)(T) 10310-21-1 1g $34 2024-06-20 Buy
TCI Chemical A1407 2-Amino-6-chloropurine >98.0%(HPLC)(T) 10310-21-1 5g $101 2024-06-20 Buy
Product number Packaging Price Buy
109789 1g $25 Buy
109789 5g $50 Buy
PHR2861 50MG $424 Buy
A1407 1g $34 Buy
A1407 5g $101 Buy

6-Chloroguanine Chemical Properties,Uses,Production

Description

6-Chloroguanine, also be known as 2-Amino-6-chloropurine may be used in the enzymatic synthesis of 2′-deoxyguanosine, 9-alkyl purines (R)and (S)-N(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases. It is also useful during the synthesis of guanine.

Description

2-Amino-6-chloropurine is a precursor in the synthesis of nucleoside analogs with antiviral activity against Epstein-Barr virus (EBV) and human herpes virus 6 (HHV-6).

Chemical Properties

white to light yellow crystal powder

Uses

2-Amino-6-chloropurine may be used:

  • in the enzymatic synthesis of 2′-deoxyguanosine
  • in the synthesis of 9-alkyl purines
  • in the synthesis of (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases

Uses

2-Amino-6-chloropurine finds its uses in the enzymatic synthesis of 2?-deoxyguanosine, 9-alkyl purines and (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases.

Definition

ChEBI: 6-chloroguanine is an organochlorine compound that is 7H-purin-2-amine substituted by a chloro group at position 6. It is a member of 2-aminopurines and an organochlorine compound.

General Description

2-Amino-6-chloropurine is a 6-substituted purine. Tautomeric purine forms of 2-amino-6-chloropurine were investigated by vibrational spectroscopy and quantum chemical method.

Synthesis

Preparation of 2-amino-6-chloropurine:
Diacetyl guanine (8.0g, 0.034 moles), triethyimethylammonium chloride (15.45g, 0.102 moles), and triethylamine (4.74 mis, 0.034 moles) were heated together with stirring in acetonitrile (70mls) to 50°C. Phosphorus oxychioride (6.34 mis, 0.068 moles) was then added and stirring continued for 4 hours. The reaction mixture was cooled and then added to aqueous sodium hydroxide solution (20g in 300mls water). The reaction mixture was heated to 80°C for 2 hours and then the volume made up to 300 mis with water. The mixture was cooled to 25°C and the pH adjuster to 7 using 10% hydrochloric acid. The resulting slurry was stirred for fifteen minutes and the product filtered off and washed with water 30 mis and then dried at 80°C under vacuum to give a cream/off white coloured product, 2-amino-6-chioropurine 4.69 g (74.6% yield).

Global( 631)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou Measure Life Technology Co., LTD
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Hebei Mojin Biotechnology Co., Ltd
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Henan Bao Enluo International TradeCo.,LTD
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Henan Fengda Chemical Co., Ltd
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Capot Chemical Co.,Ltd.
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Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 14666 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21709 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32294 60
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29919 58

View Lastest Price from 6-Chloroguanine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
trực tiếp đá gà hôm nayLiên kết đăng nhập 2025-01-29 6-Chloroguanine
10310-21-1
US $0.00 / Kg/Drum 100g/Bag 99% 100mt/year Jinan Finer Chemical Co., Ltd
trực tiếp đá gà hôm nayLiên kết đăng nhập 2025-01-11 2-Amino-6-chloropurine
10310-21-1
US $122.00-1.00 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
trực tiếp đá gà hôm nayLiên kết đăng nhập 2024-08-07 6-Chloroguanine
10310-21-1
US $0.00-0.00 / kg 1kg 98% 500kg per month Yunbio Tech Co.,Ltd.
  • trực tiếp đá gà hôm nayLiên kết đăng nhập
  • 6-Chloroguanine
    10310-21-1
  • US $0.00 / Kg/Drum
  • 99%
  • Jinan Finer Chemical Co., Ltd
AURORA KA-689 6-CHLORO-9H-PURIN-2-YLAMINE 6-CHLOROGUANINE 6-Chloro-7H-purin-2-ylamine TIMTEC-BB SBB003863 6-Chloro-2-purinamine 6-Chloro-7H-purine-2-amine 2-Amino-6-chloropuri 6-chloro-9H-purin-2-amine(SALTDATA: FREE) 2-aMino-6-cyanopurine 2-AMino-9H-purine-6-carbonitrile 2-AMino-6-chlorpurin FaMciclovir Related CoMpound F 2-AMino-6-chloropurine, 98+% 2 - aMino - 6 - chlorine purine Famciclovir Related Compound F (25 mg) (2-Amino-6-chloropurine) 1H-Purin-2-amine, 6-chloro- (9CI) 2-Amino-6-chlorpurine Purine, 2-amino-6-chloro- 6-chloro-1h-purin-2-amin 6-chloro-1h-purin-2-amine FAMCICLOVIR INTERMEDIATES 9-(4-acetoxy-3-acetoxymethylbut-1-y)-2-amino-6-chloro purine 2-Amino-6-chloro-9H-purine 6-CHLOROGUANINE CRYSTALLINE 2-Amino-6-Chloropurine(6-Chloroguanine) 1H-Purin-2-amine, 6-chloro- 2-Amino-6-chloro-9H-purine 99% 6-CHLOROGUANINE extrapure 4-Chloro-1,3,5,7-tetraaza-1H-indene-6-amine Clofarabine Impurity 3 2-Amino-6-chloropurine > 2-Amino-6-Chloro-Purin,>98% Famciclovir USP RC F 6-Chloroguanine USP/EP/BP Famciclovir Related Compound F (2-Amino-6-chloropurine) (1269141) 2-amino-6-chloro-purin 2-AMINO-6-CHLOROPURINE 6-CHLORO-2-AMINOPURINE 9H-PURIN-2-AMINE, 6-CHLORO- 6-Chloro-7H-purin-2-amine 2-AMINO-6-CHLOROPURINE (2A6ClP) Famciclovir USP Related Compound F 2-Amino-6-c2-Amino-6-chloropurinehloropurine Famciclovir Related Compound F (2-Amino-6-chloropurine) 10310-21-1 10310-21-2 233-686-7 C5H4CIN5 C5H4ClN2 Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Purines Biochemistry Nucleobases and their analogs Nucleosides, Nucleotides & Related Reagents Nucleic acids Bases & Related Reagents
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