- Formononetin
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- $0.00 / 1kg
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2025-03-29
- CAS:485-72-3
- Min. Order: 0.10000000149011612kg
- Purity: ≥98%HPLC
- Supply Ability: 20tons
- Formononetin
-
- $0.00 / 10MG
-
2025-03-28
- CAS:485-72-3
- Min. Order: 10MG
- Purity: 98% HPLC
- Supply Ability: 100KG
- Formononetin
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- $0.00 / 25kg
-
2025-03-28
- CAS:485-72-3
- Min. Order: 25kg
- Purity: HPLC>99%
- Supply Ability: Inquiry
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| | Formononetin Basic information |
| | Formononetin Chemical Properties |
| Melting point | 256-260 °C | | Boiling point | 331.43°C (rough estimate) | | density | 1.1529 (rough estimate) | | vapor pressure | 0Pa at 25℃ | | refractive index | 1.4350 (estimate) | | storage temp. | 2-8°C | | solubility | Soluble in DMSO (up to 100 mg/ml). | | pka | 6.99±0.20(Predicted) | | form | Powder | | color | White to light beige | | λmax | 300nm(EtOH)(lit.) | | Merck | 14,4244 | | BRN | 237979 | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. | | InChIKey | HKQYGTCOTHHOMP-UHFFFAOYSA-N | | LogP | 1.7 at 25℃ | | CAS DataBase Reference | 485-72-3(CAS DataBase Reference) | | EPA Substance Registry System | |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 37/39-26-36 | | WGK Germany | 3 | | RTECS | DJ3100114 | | HS Code | 29329990 |
| | Formononetin Usage And Synthesis |
| Description | Formononetin (485-72-3) is a naturally occurring isoflavone isolated from Astragalus and other plants. Increases adipocyte thermogenesis by modulating PPARγ activity.1?Activates AMP-activated protein kinase/β-catenin signaling to inhibit adipogenesis.2?Accelerates wound repair by increasing expression of Egr-1 transcription factor.3?Potential cancer chemopreventive and chemotherapeutic.4?Provides neuroprotection against traumatic brain injury by inhibition of neuroinflammation in a rat model.5 | | Chemical Properties | off-white powder | | Uses | An isoflavone found in a variety of plants. When metabolized in the rumen this compound transforms into a potent estrogen. | | Uses | Formononetin is an isoflavonoid phytoestrogenic compound found in soy-based foods and is the precursor of daidzein . It acts as an agonist of the aryl hydrocarbon receptor with an EC50 value of 0.13 μM. Formononetin has been reported to possess antitumor and antiviral activity. | | Uses | Formononetin is an isoflavone found as one of the main plant estrogens in animal feed. When metabolized in the rumen this compound transforms into a potent estrogen. | | Definition | ChEBI: Formononetin is a member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by a methoxy group at position 4'. It has a role as a phytoestrogen and a plant metabolite. It is a member of 7-hydroxyisoflavones and a member of 4'-methoxyisoflavones. It is functionally related to a daidzein. It is a conjugate acid of a formononetin(1-). | | General Description | Formononetin belongs to the isoflavones class of polyphenols. | | Flammability and Explosibility | Not classified | | Biochem/physiol Actions | Isoflavone found in red clover. Effective against Giardia lamblia infection, at least partially by inducing detachment of trophozoites from intestinal mucosa. | | References | 1) Nie?et al.?(2018),?The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPARγ activity; Br. J. Pharmacol.,?175?1439
2) Gautam?et al.?(2017),?Formononetin, an isoflavone, activates AMO-activated protein kinase/?β-catenin signaling to inhibit adipogenesis and rescues C57BL/6 mice from high-fat diet-induced obesity and bone loss; Br. J. Nutrit.,?117?645
3) Huh?et al. (2011),?Formononetin accelerates wound repair by the regulation of early growth response factor-1 transcription factor through the phosphorylation of the ERK and p38 MAPK pathways; Int. Immunopharmacol.,?11?46
4) Ong?et al.?(2019),?Focus on Formononetin: Anticancer Potential and Molecular Targets; Cancers (Basel),?11?E611
5) Li?et al.?(2018),?Neuroprotective effect of formononetin against TBI in rats via suppressing inflammatory reaction in cortical neurons; Biomed. Pharmacother.,?106?349 |
| | Formononetin Preparation Products And Raw materials |
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