Ivermectin
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Ivermectin 속성
- 알파
- D +71.5 ± 3° (c = 0.755 in chloroform)
- RTECS 번호
- IH7891500
- 저장 조건
- 2-8°C
- 용해도
- H2O: ≤1.0% KF
- 물리적 상태
- 가루
- 색상
- 하얀색
- 수용성
- 4mg/L(온도는 명시되지 않음)
- BCS Class
- 4/3
- 안정성
- 최대 3개월 동안 -20°에서 DMSO 또는 에탄올에 보관
- InChIKey
- AZSNMRSAGSSBNP-XPNPUAGNSA-N
- CAS 데이터베이스
- 70288-86-7(CAS DataBase Reference)
- EPA
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T,Xn,T+ | ||
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위험 카페고리 넘버 | 61-25-36-36/38-22-28 | ||
안전지침서 | 53-26-45-36-36/37-28 | ||
유엔번호(UN No.) | UN 2811 6.1/PG 2 | ||
WGK 독일 | 3 | ||
위험 등급 | 6.1(a) | ||
포장분류 | II | ||
HS 번호 | 29322090 | ||
독성 | LD50 in dogs, rhesus monkeys (mg/kg): about 80, more than 24 orally. (MSDS Merck & Co. Inc., 2003) |
Ivermectin C화학적 특성, 용도, 생산
개요
Ivermectin is an antiparasitic agent effective in the treatment of onchocerciasis, or "river blindness". Since ivermectin acts to prevent the adult worm from producing microfilariae, it needs to be administered only once or twice a year.화학적 성질
Crystalline Solid제조 방법
The synthesis of ivermectin involves the hydrogenation of the naturally occurring avermectin B1 (abamectin) at the double bond linking C-22 and C-23. This results in a mixture of two homologues, 22, 23-dihydroavermectin B1a (H2B1a) and 22, 23-dihydroavermectin B1b (H2 B1b). The a- and b- nomenclature refers to the presence on C-25, of either a secondary butyl side chain or an isopropyl group, respectively. The biological activities of H2B1a and H2B1b are similar. Large-scale separation of the two homologues is not practical, and, hence, ivermectin is marketed as a mixture of H2 B1a (>80%) and H2 B1b (<20%).Indications
Ivermectin (Mectizan) acts on parasite-specific inhibitory glutamate-gated chloride channels that are phylogenetically related to vertebrate GABA-gated chloride channels. Ivermectin causes hyperpolarization of the parasite cell membrane and muscle paralysis.At higher doses it can potentiate GABA-gated chloride channels. It does not cross the blood-brain barrier and therefore has no paralytic action in mammals, since GABA-regulated transmission occurs only in the central nervous system (CNS). Ivermectin is administered by the oral and subcutaneous routes. It is rapidly absorbed. Most of the drug is excreted unaltered in the feces. The half-life is approximately 12 hours.Antimicrobial activity
It is also active against O. volvulus and other filarial worms, but the effect is chiefly directed against the larval forms (microfilariae). Uniquely among anthelmintic agents it exhibits activity against some ectoparasites, including Sarcoptes scabiei.생물학적 활성
Positive allosteric modulator of the α 7 neuronal nicotinic acetylcholine receptor and the purinergic P2X 4 receptor. Antihelmintic. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM).Clinical Use
OnchocerciasisNon-disseminated strongyloidiasis
Lymphatic filariasis (in combination with albendazole)
Scabies
If the patient is harboring Asc. lumbricoides, the worms will be passed in the feces. Head lice will also be killed, which is very much welcomed by the treated patients. Ivermectin has been widely used in the veterinary field, where use is also made of its effect on ectoparasites.
부작용
In the treatment of onchocerciasis mild Mazzotti-type reactions occur, with occasional neurological problems. Although it is highly effective against L. loa, care must be taken to avoid treating patients with high microfilarial counts: there is one report of a patient with a concomitant L. loa infection who died when treated for onchocerciasis. Mild gastrointestinal and nervous system signs may occur following treatment for strongyloidiasis.신진 대사
Ivermectin is rapidly absorbed, is bound to a great extent to plasma protein, and is excreted in the urine or feces either unchanged or as the 3′-O-demethyl-22,23-dihydroavermectin B1α or as the dihydroavermectin B1α monosaccharide. The absorption of IVM is significantly affected by the presence of alcohol. Administration of IVM as an alcoholic solution may result in as much as a 100% increase in absorption.Ivermectin 준비 용품 및 원자재
원자재
2-(5-methyl-2-propan-2-yl-phenoxy)ethanamine
트리페닐포스핀
포름아미드
Rhodium (III) chloride trihydrate
수소
하이드라진, 모노수화물
아버멕틴 B1
준비 용품
Ivermectin 공급 업체
글로벌( 799)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei ZB Gamay Biological Technology Co.,Ltd | +86-031189171450 +86-15632359451 |
chem@zbvet.net | China | 222 | 58 |
Masteam Bio-tech Co., Ltd. | +86-15200345168 +86-15200345168 |
bruce.lei@masteam.com | CHINA | 153 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8822 | 58 |
Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 |
kathy@hbyinsheng.com | China | 3582 | 58 |
Hebei Lingding Biotechnology Co., Ltd. | +86-18031140164 +86-19933155420 |
erin@hbldbiotech.com | China | 878 | 58 |
Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 |
xie@china-sinoway.com | China | 992 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12467 | 58 |
Shanghai Affida new material science and technology center | +undefined15081010295 |
2691956269@qq.com | China | 371 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 1034 | 58 |
XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 18829239519 |
sales06@tgybio.com | China | 959 | 58 |
Ivermectin 관련 검색:
디스프로슘 트리(2,2,6,6-테트라메틸-3,5-헵탄디오네이트) 코발트(II) 아세틸아세토네이트 하이드레이트 아세틸아세토산 제2철 실버 아세틸아세토네이트 아세틸아세톤산 구리 알루미늄 아세틸아세토네이트
Ivermectin EP Impurity I
Isoxepac
Itaconic anhydride
Itaconic acid
Ivermectin B1a
Tris(2,4-pentanedionato)chroMiuM(III)
METHYL ISOCYANOACETATE
Benzyl isocyanide
DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
Ethyl isocyanoacetate
SALCOMINE
PHENYLSELENOL