ChemicalBook >> CAS DataBase List >>Propiophenone
Propiophenone
- CAS No.
- 93-55-0
- Chemical Name:
- Propiophenone
- Synonyms
- 1-PHENYL-1-PROPANONE;phenylpropanone;1-phenyl-propan-1-one;Propiophenon;ETHYL PHENYL KETONE;FEMA 3469;usafek-1235;Propiophene;USAF ek-1235;phenylpropone
- CBNumber:
- CB8695754
- Molecular Formula:
- C9H10O
- Molecular Weight:
- 134.18
- MDL Number:
- MFCD00009309
- MOL File:
- 93-55-0.mol
- MSDS File:
- SDS
Last updated:2024-11-28 16:31:44
Melting point | 17-19 °C(lit.) |
---|---|
Boiling point | 218 °C(lit.) |
Density | 1.009 g/mL at 25 °C(lit.) |
vapor pressure | 1 mm Hg ( 50 °C) |
refractive index |
n |
FEMA | |
Flash point | 190 °F |
storage temp. | Store below +30°C. |
solubility | Difficult to mix. |
form | Liquid |
color | Clear colorless to light yellow |
Odor | at 10.00 % in dipropylene glycol. hawthorn lilac floral aromatic cherry herbal |
Odor Type | floral |
Water Solubility | INSOLUBLE |
Merck | 14,7830 |
JECFA Number | 824 |
BRN | 606215 |
Dielectric constant | 15.5 |
Stability | Stable. Incompatible with strong oxidizing agents, strong bases. |
InChIKey | KRIOVPPHQSLHCZ-UHFFFAOYSA-N |
LogP | 2.71 |
Substances Added to Food (formerly EAFUS) | |
CAS DataBase Reference | 93-55-0(CAS DataBase Reference) |
EWG's Food Scores | |
FDA UNII | |
NIST Chemistry Reference | |
EPA Substance Registry System |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Danger | |||||||||
Hazard statements | H227 | |||||||||
Precautionary statements | P210e-P280a-P370+P378a-P403+P235-P501a | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36 | |||||||||
WGK Germany | 2 | |||||||||
RTECS | UG7175000 | |||||||||
TSCA | Yes | |||||||||
HS Code | 2914 39 00 | |||||||||
Toxicity | LD50 orally in Rabbit: 4490 mg/kg LD50 dermal Rabbit 4490 mg/kg | |||||||||
NFPA 704 |
|
Propiophenone Chemical Properties,Uses,Production
Description
Propiophenone belongs to the family of acetophenones, which is present in some certain cheese, coffee and coffee products, tea and roasted nuts with sweet-smelling odor. It is wisely used as an intermediate in the preparation of other organic compounds, such as synthetic aryl alkenes, like cinnamic acids. It is also a useful intermediate for pharmaceuticals production, such as ephedrine, propiophenone derivatives (cathinone and methcathinone), and especially for the preparation of nervous system drugs (anxiolytic and hypnotic drugs). Besides, due to its naturally pleasant flowery odor, propiophenone can be used as a component in some perfumes.References
//en.wikipedia.org/wiki/Propiophenone
//pubchem.ncbi.nlm.nih.gov/compound/7148#section=Top
//www.chemicalland21.com/industrialchem/organic/PROPIOPHENONE.htm
//www.alfa.com/en/catalog/A15140/
Chemical Properties
Propiophenone has a strong, flowery odor. 1-Phenyl-1-propanone is a colorless liquid with a flowery odor, insoluble in water, readily soluble in organic solvents. Typical reactions can be carried out at the methylene group, the carbonyl group, and at the aromatic nucleus.Occurrence
Reported found in coffee, roasted filberts, roasted peanuts and roasted green tea. Also reported found in Camembert cheese, black tea, roasted macadamia nut, tamarind, dried bonito, cherimoya and sapodilla fruit.Uses
1-Phenyl-1-propanone is used mainly as an intermediate for pharmaceuticals such as DPropoxyphen, phenylpropanolamine, and Phenmetrazine.Uses
Propiophenone is an aryl ketone used in the preparation of pharmaceutical and organic compounds. Propiophenone is used in perfumes as well as in the preparation of neurochemical compounds such as ephe drines.Uses
In perfumery; in the synthesis of ephedrine and related Compounds.Definition
ChEBI: Propiophenone is an aromatic ketone in which the two substituents on the carbonyl C atom are phenyl and ethyl. It has a role as a fragrance.Production Methods
Propiophenone is produced by the Friedel–Crafts acylation of benzene with propionic acid chloride in the presence of aluminum chloride. It may also be produced by the reaction of benzoic acid and propionic acid using a calcium acetate– aluminum oxide catalyst.Synthesis Reference(s)
The Journal of Organic Chemistry, 60, p. 2430, 1995 DOI:
Tetrahedron Letters, 30, p. 4819, 1989 DOI:
Flammability and Explosibility
Not classifiedSafety Profile
Poison by intraperitoneal route. Moderately toxic by subcutaneous route. Mildly toxic by ingestion and skin contact. A skin and eye irritant. A flammable liquid when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.Propiophenone Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
fluorescent brightener 311
D/L-AMPHETAMINE HYDROCHLORIDE
Pravastatin
D-(-)-THREO-2-AMINO-1-(4-NITROPHENYL)-1,3-PROPANEDIOL
Bipariden
1of4
1-phenyl-1-propanon
1-phenylpropanone
1-phenylpropanone-1
1-Propanone,1-phenyl-
Ketone, ethyl phenyl
ketone,ethylphenyl
lithylphenyllwton
phenylpropone
Propionphenone
USAF ek-1235
usafek-1235
αthylenphenylketon
Propiophenone Vetec(TM) reagent grade, 99%
Ethyl phenyl ketone
1-Phenyl-1-propanone
Propionylbenzene
Ethyl Phenyl Ketone
Propionylbenzene
PROPIOPHENONE / 1-PHENYL-1-PROPANONE
PROPIOPHENONE pure
FEMA 3469
PHENYL ETHYL KETONE
PROPIONYLBENZENE
PROPIOPHENONE
AKOS BBS-00003274
Propiophene
PROPIOPHENONE 99+%
PROPIOPHENONE FOR SYNTHESIS 1 L
PROPIOPHENONE FOR SYNTHESIS 250 ML
Proopiophenone
2-(diethoxyphosphorylthio)-N,N-dimethylethanamine
Propiophenone>
Propoiphenone
1-phenyl-propan-1-one
1-PHENYL-1-PROPANONE
phenylpropanone
ETHYL PHENYL KETONE
Propiophenon
Bupropion Propiophenone Impurity
Glycine Impurity 11
93-55-0
54419-32-7
C6D5COCH2CH3
C6H5COC2H5
C6H5COCH2CH3
C6H5CH2COCH3
C2H5COC6H5
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