ChemicalBook >> CAS DataBase List >>Tolclofos-methyl
Tolclofos-methyl
- CAS No.
- 57018-04-9
- Chemical Name:
- Tolclofos-methyl
- Synonyms
- S-3349;RIZOLEX;Basilex;Risolex;Risolex(TM);Tolcofos-methyl;olclofos-methyl;Methyl tolclofo;TOLCLOFOS-METHYL;Methyl tolclofos
- CBNumber:
- CB2451996
- Molecular Formula:
- C9H11Cl2O3PS
- Molecular Weight:
- 301.13
- MDL Number:
- MFCD00078741
- MOL File:
- 57018-04-9.mol
Last updated:2024-05-25 18:01:03
| Melting point | 78-80°C |
|---|---|
| Boiling point | 338.5±52.0 °C(Predicted) |
| Density | 1.401±0.06 g/cm3(Predicted) |
| vapor pressure | 1.84 x 10-3 (Pa 25 °C) |
| Flash point | >100 °C |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly) |
| Water Solubility | 1.10 mg l-1 (25 °C) |
| Merck | 13,9587 |
| BRN | 2136521 |
| InChIKey | OBZIQQJJIKNWNO-UHFFFAOYSA-N |
| LogP | 4.560 |
| CAS DataBase Reference | 57018-04-9(CAS DataBase Reference) |
| FDA UNII | |
| NIST Chemistry Reference | |
| Pesticides Freedom of Information Act (FOIA) | |
| EPA Substance Registry System |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317-H410 |
| Precautionary statements | P261-P272-P273-P280-P302+P352-P333+P313 |
| Hazard Codes | Xi,N |
| Risk Statements | 43-50/53 |
| Safety Statements | 22-24/25-61-60-37-24 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| RTECS | TF0460000 |
| HS Code | 29201900 |
| Toxicity | LD50 in male, female rats, male, female mice (mg/kg): ~5000, ~5000, 3500, 3600 orally; all >5000 dermally; ~5000, 4900, 1070, 1260 i.p.; all >5000 s.c. (Ohtsuki, Fujinami) |
Tolclofos-methyl price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 31209 | Tolclofos-methyl PESTANAL | 57018-04-9 | 250mg | $49.56 | 2025-03-01 | Buy |
| TRC | T535265 | Tolclofos-methyl | 57018-04-9 | 1g | $215 | 2022-12-16 | Buy |
| ChemScene | CS-5201 | Tolclofos-methyl 96.51% | 57018-04-9 | 500mg | $60 | 2022-12-16 | Buy |
| American Custom Chemicals Corporation | PST0000303 | TOLCLOFOS-METHYL 95.00% | 57018-04-9 | 5MG | $501.25 | 2022-12-16 | Buy |
| Medical Isotopes, Inc. | 99597 | Tolclofos-methyl | 57018-04-9 | 1g | $575 | 2022-12-16 | Buy |
Tolclofos-methyl Chemical Properties,Uses,Production
Uses
Tolclofos-methyl is a non-systemic organophosphorus fungicide with both protective and curative activities that control soil-borne diseases caused by Rhizoctonia solani, Corticium rolfsii, Tphula incamata and Typhula ishikariensis in/on potatoes, sugar beet, cotton and peanuts.Uses
Agricultural fungicide.Definition
ChEBI: An organic thiophosphate that is 2,6-dichloro-4-methylphenol in which the hydrogen of the hydroxy group group has been replaced by a dimethoxyphosphorothioyl group. Tolclofos-methyl is a phospholipid biosynthesis inhibitor and fungicide that is used for co trolling soil-borne diseases caused by Typhula incarnata, Corticium rolfsii, Typhula ishikariensis, and Rhizoctonia solani.Metabolic pathway
Tolclofos-methyl underwent common degradation and metabolic pathways in water, soil, plants and animals. These reactions are well documented for most organophosphorus compounds and include oxidative desulfuration, hydroxylation/oxidation of the 4-methyl group to the alcohol and carboxylic acid, cleavage of the P-O-aryl linkage, O-demethylation and conjugation. In addition to the above reactions, photolytic isomerisation to the thionate (P=S) was also observed. A schematic presentation of the primary metabolic pathways for tolclofosmethyl is illustrated in Scheme 1.Degradation
[14C-phenyl]Tolclofos-methyl(1) was stable to hydrolytic degradation at
pH 5, 7 and 9 at 22°C with DT50 values of 139, 417 and 238 days,
respectively. Higher temperature led to a more rapid hydrolysis and two
hydrolysis products were detected. O-Demethylation and oxidative desulfuration
were the major reactions to yield 2,6-dichloro-p-tolyl methyl
hydrogen phosphorothioate (2) and toclofos-methyl oxon (O-2,6-dichlorop-
tolyl O,O-dimethyl phosphate, 3), respectively. Cleavage of the P-O-aryl
linkage yielded 2,6-dichloro-4-methylphenol(4) as a minor degradation
product (WHO, 1994).
Tolclofos-methyl degraded in water under natural sunlight irradiation
with DT50 values of 44 days (in distilled water), 15-28 days (in natural
river and pond water) and less than 2 days in 2% acetone/water. The
major degradation reactions included oxidative desulfuration to yield
compound 3 and O-demethylation to yield compound 2. The major
photodegradation products in river and pond waters and soil thinlayer
surfaces were compounds 2, 3, 4 and the O-demethylated 3 (2,6-
dichloro-p-tolyl methyl hydrogen phosphate, 5) (Mikami et al., 1984).
In acetone solution, demethylation of the isomerisation product [2,6-
dichloro-p-tolyl O,S-dimethyl phosphorothioate (6)] yielded 2,6-dichlorop-
tolyl S-methyl hydrogen phosphorothioate (7) and 2,6-dichloro-p-tolyl
dihydrogen phosphate (8) as the major photodegradates (Mikami et al.,
1984).
Toxicity evaluation
Its acute oral toxicity is very low in comparison with a thio-ester type of other organophosphorus fungicides (edifenphos, iprobenfos, and pyrazophos).
Synthesis of Tolclofos-methyl from 2,6-Dichloro-4-methylphenol and Dimethyl chlorothiophosphate and Sodium sulfate
Tolclofos-methyl Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Global( 158)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21696 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9353 | 55 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 12757 | 58 |
View Lastest Price from Tolclofos-methyl manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-09-06 | Tolclofos-methyl
57018-04-9
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Guanlang Biotechnology Co., Ltd. |
-
- Tolclofos-methyl
57018-04-9
- US $0.00-0.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
57018-04-9(Tolclofos-methyl)Related Search:
2,6-dichloro-4-methylphenyl o,o-dimethyl phosphorothioate
Dimethyl O-(2,6-dichloro-4-methylphenyl) phosphorothioate
S-3349
RIZOLEX
O-(2,6-DICHLORO-4-METHYLPHENYL) O,O-DIMETHYL PHOSPHOROTHIOATE
TOLCLOFOS-METHYL
Basilex
Dichloro-4-methylphenyl-O,O-dimethyl phosphorothioate
o-(2,6-Dichloro-4-methylphenyl) o,o-dimethyl thiophosphate
o-(2,6-dichloro-p-tolyl)o,o-dimethylesterofphosphorothioicacid
O-(2,6-Dichloro-p-tolyl)-O,O-dimethylthiophosphate
o,o-dimethylo-(2,6-dichloro-4-methylphenyl)phosphorothioate
Phosphorothioic acid, O-(2,6-dichloro-4-methylphenyl) O,O-dimethyl ester
Phosphorothioicacid,esters,O-(2,6-dichloro-4-methylphenyl)-O,O-dimethylester
phosphorothioicacid,o-(2,6-dichloro-4-methylphenyl)o,o-dimethylester
phosphorothioicacid,o-(2,6-dichloro-p-tolyl)o,o-dimethylester
Risolex
Tolcofos-methyl
BENZTHIAZURON PESTANAL, 100 MG
tolclofos-methyl (bsi,iso)
TOLCHLOFOS-METHYL
O，O-dimethyl-O-(2,6-dichloro-p-tolyl) phosphorothioate
(2,6-Dichloro-4-methylphenoxy)-dimethoxy-sulfanylidenephosphorane
Phosphorothioic acid O-(2,6-dichloro-4-methylphenyl) O,O-dimethyl
Thiophosphoric acid O-(2,6-dichloro-4-methylphenyl)O,O-dimethyl ester
Thiophosphoric acid O,O-dimethyl O-(2,6-dichloro-4-methylphenyl) ester
Thiophosphoric acid=O-(2,6-dichloro-4-methylphenyl)=O,O-dimethyl ester
O-2,6-DICHLORO-P-TOLYLO,O-DIMETHYLPHOSPHOROTHIOATE
Tolclofos-methyl Standard
Tolclofos-methyl Solution, 100ppm
Tolclofos-Methyl 500mg [57018-04-9]
Risolex(TM)
Tolclofos-methyl Solution, 1000ppm
Tolclofos-methyl@1000 μg/mL in Acetone
Tolclofos-methyl @100 μg/mL in MeOH
Tolchlophos-methyl
Tolclofos-MethylStock,100mg/L,1ml
olclofos-methyl
TIANFU-CHEM - Tolclofos-methyl
Methyl tolclofos
Methyl tolclofo
Tolclofos-methyl Solution in Methanol
Tolclofos-methyl Solution in Hexane
57018-04-9
C9H11Cl2O3PS
FUNGICIDE