Chemical Safety Data Sheet MSDS / SDS
Chloramphenicol
Revision Date:2025-04-20Revision Number:1
Product identifier
- Product name: Chloramphenicol
- CBnumber: CB3364529
- CAS: 56-75-7
- EINECS Number: 200-287-4
- Synonyms: CHLORAMPHENICOL,CAF
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 400-158-6606
Classification of the substance or mixture
Serious eye damage, Category 1Carcinogenicity, Category 2Reproductive toxicity, Category 2
Label elements
Pictogram(s)
- Signal wordDanger
H225 Highly Flammable liquid and vapourH303 May be harmfulif swallowedH333 May be harmful if inhaledH340 May cause genetic defectsH350 May cause cancerH351 Suspected of causing cancerH361 Suspected of damaging fertility or the unborn childH371 May cause damage to organsH372 Causes damage to organs through prolonged or repeated exposureH373 May cause damage to organs through prolonged or repeated exposure
Precautionary statement(s)
P201 Obtain special instructions before use.P202 Do not handle until all safety precautions have been read and understood.P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.P260 Do not breathe dust/fume/gas/mist/vapours/spray.P264 Wash hands thoroughly after handling.P264 Wash skin thouroughly after handling.P270 Do not eat, drink or smoke when using this product.P280 Wear protective gloves/protective clothing/eye protection/face protection.P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.P308+P313 IF exposed or concerned: Get medical advice/attention.P405 Store locked up.P501 Dispose of contents/container to..…
Prevention
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P203 Obtain, read and follow all safety instructions before use.
Response
P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P317 Get medical help. P318 IF exposed or concerned, get medical advice.
Storage
P405 Store locked up.
Disposal
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards
no data available
Substance
- Product name: Chloramphenicol
- Synonyms: CHLORAMPHENICOL,CAF
- CAS: 56-75-7
- EC number: 200-287-4
- MF: C11H12Cl2N2O5
- MW: 323.13
Description of first aid measures
If inhaled Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.
Following skin contact
Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.
Following eye contact
Rinse with pure water for at least 15 minutes. Consult a doctor.
Following ingestion
Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.
Most important symptoms and effects, both acute and delayed
no data available
Indication of any immediate medical attention and special treatment needed
Emergency and supportive measures; 1. Maintain an open airway and assist ventilation if necessary. 2. Treat coma, seizures, hypotension, anaphylaxis, and hemolysis if they occur. 3. WordStr fluid losses resulting form gastroenteritis with intravenous crystalloids. ... /Antibacterial Agents/.
Extinguishing media
Use dry chemical, carbon dioxide or alcohol-resistant foam.
Specific Hazards Arising from the Chemical
no data available
Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
NFPA 704
2
1
0
| HEALTH | 2 | Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine) | |
| FIRE | 1 | Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.
Environmental precautions
Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.
Methods and materials for containment and cleaning up
PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. Chemical Carcinogens
Precautions for safe handling
Handling in a well ventilated place.
Wear suitable protective clothing.
Avoid contact with skin and eyes.
Avoid formation of dust and aerosols.
Use non-sparking tools.
Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. Chemical Carcinogens
Control parameters
Occupational Exposure limit values| Component | Chloramphenicol | |||
|---|---|---|---|---|
| CAS No. | 56-75-7 | |||
| Limit value - Eight hours | Limit value - Short term | |||
| ppm | mg/m3 | ppm | mg/m3 | |
| Latvia | ? | 1 | ? | ? |
| Remarks | ||||
no data available
Exposure controls
Ensure adequate ventilation.
Handle in accordance with good industrial hygiene and safety practice.
Set up emergency exits and the risk-elimination area.
Individual protection measures
Eye/face protectionWear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).
Skin protection
Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Respiratory protection
If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.
Thermal hazards
no data available
Information on basic physicochemical properties
- Physical statepowder
- Colourwhite
- Odourno data available
- Melting point/freezing point87°C(lit.)
- Boiling point or initial boiling point and boiling range 153°C/1mmHg(lit.)
- Flammabilityno data available
- Lower and upper explosion limit/flammability limitno data available
- Flash point120°C(lit.)
- Auto-ignition temperatureno data available
- Decomposition temperatureno data available
- pHNEUTRAL TO LITMUS
- Kinematic viscosityno data available
- Solubilityabsolute ethanol: soluble5-20mg/mL (as a stock solution)
- Partition coefficient n-octanol/waterno data available
- Vapour pressure1.7X10-12 mm Hg at 25 deg C /Estimated/
- Density and/or relative density1.547 g/cm3
- Relative vapour density no data available
- Particle characteristics no data available
Reactivity
no data available
Chemical stability
Neutral and acid solutions are stable on heating
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Stable in the solid state as a bulk drug and when present in solid dosage forms. (IARC) Sensitive to light. (CRC Handbook) Neutral and acid solutions are stable on heating. (Merck)
Hazardous decomposition products
no data available
Acute toxicity
- Oral: no data available
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Evaluation: There is limited evidence for the carcinogenicity of chloramphenicol in humans. There is inadequate evidence for the carcinogenicity of chloramphenicol in experimental animals. The Working Group also took note of the following information. Chloramphenicol induces aplastic anemia, and this condition is related to the occurrence of leukemia. Overall Evaluation: Chloramphenicol is probably carcinogenic to humans (Group 2A).
Reproductive toxicity
no data available
STOT-single exposure
no data available
STOT-repeated exposure
no data available
Aspiration hazard
no data available
Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
Persistence and degradability
AEROBIC: Using adapted activated sludge as the inoculum, chloramphenicol degraded 86.2 percent with a biodegradation rate of 3.3 mg COD per gram per hour(1). Chloramphenicol has also been reported to be degraded by intestinal bacteria via amidolysis to 18 observed metabolites with 2-amino-1-(p-nitrophenyl)-1,3-propanediol and its p-aminophenyl reduction product as the major products(2). However, in these experiments, the metabolic studies were carried out in inoculated-aerated nutrient broth media that did not simulate the habitat of the bacteria(2). Half-lives in marine and freshwater sediment of 2.4 to 18.4 days and <12 days, respectively, have been reported, although specific fate pathways were not identified(3).
Bioaccumulative potential
An estimated BCF of <1 was calculated for chloramphenicol(SRC), using a log Kow of 1.14(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
Mobility in soil
The Koc of chloramphenicol is estimated as 99(SRC), using a log Kow of 1.14(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that chloramphenicol is expected to have high mobility in soil.
Other adverse effects
no data available
Disposal methods
Product
The material can be disposed of by removal to
a licensed chemical destruction plant or by controlled incineration
with flue gas scrubbing. Do not contaminate water, foodstuffs,
feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and
offered for recycling or reconditioning.
Alternatively, the packaging can be punctured to
make it unusable for other purposes and then be disposed of
in a sanitary landfill. Controlled incineration
with flue gas scrubbing is possible for combustible packaging materials.
UN Number
ADR/RID: Not dangerous goods. (For reference only, please check.)IMDG: Not dangerous goods. (For reference only, please check.)IATA: Not dangerous goods. (For reference only, please check.)
UN Proper Shipping Name
ADR/RID: Not dangerous goods. (For reference only, please check.)IMDG: Not dangerous goods. (For reference only, please check.)IATA: Not dangerous goods. (For reference only, please check.)
Transport hazard class(es)
ADR/RID: Not dangerous goods. (For reference only, please check.)IMDG: Not dangerous goods. (For reference only, please check.)IATA: Not dangerous goods. (For reference only, please check.)
Packing group, if applicable
ADR/RID: Not dangerous goods. (For reference only, please check.)IMDG: Not dangerous goods. (For reference only, please check.)IATA: Not dangerous goods. (For reference only, please check.)
Environmental hazards
ADR/RID: NoIMDG: NoIATA: No
Special precautions for user
no data available
Transport in bulk according to IMO instruments
no data available
Safety, health and environmental regulations specific for the product in question
European Inventory of Existing Commercial Chemical Substances (EINECS)Listed.
EC Inventory
Listed.
United States Toxic Substances Control Act (TSCA) Inventory
Listed.
China Catalog of Hazardous chemicals 2015
Not Listed.
New Zealand Inventory of Chemicals (NZIoC)
Listed.
PICCS
Listed.
Vietnam National Chemical Inventory
Listed.
IECSC
Listed.
Korea Existing Chemicals List (KECL)
Listed.
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: //www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: //toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: //www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: //www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: //cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: //chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: //www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: //www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: //echa.europa.eu/
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.