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4-Aminopyridine

CAS No.
504-24-5
Chemical Name:
4-Aminopyridine
Synonyms
PYRIDIN-4-AMINE;DalfaMpridine;FAMPRIDINE;4-AP;4-pyridinamine;AMpyra;4-PYRIDYLAMINE;Amino-4-pyridine;4-Aminopyridine,98%;4APY
CBNumber:
CB9853687
Molecular Formula:
C5H6N2
Molecular Weight:
94.11
MDL Number:
MFCD00006439
MOL File:
504-24-5.mol
MSDS File:
SDS
Last updated:2025-01-09 11:49:34

4-Aminopyridine Properties

Melting point 155-158 °C (lit.)
Boiling point 273 °C (lit.)
Density 1.26
vapor pressure 0.046Pa at 25℃
refractive index 1.5560 (estimate)
Flash point 156°C
storage temp. 2-8°C
solubility H2O: soluble50mg/mL, clear, colorless
form Crystalline Powder, Solid or Crystals
pka 9.114(at 25℃)
color White to faint grey to light yellow
Water Solubility Soluble in water(112 g/L at 20 deg C). Soluble in ethyl ether, benzene. Slightly soluble in ligroin. Very soluble in ethanol. Soluble in methanol, acetone, tetrahydrofuran, isopropanol, acetonitrile, N,N-dimethylformamide, dimethylsulfoxide, and ethanol.
Merck 14,3933
BRN 105782
Stability Hygroscopic
InChIKey NUKYPUAOHBNCPY-UHFFFAOYSA-N
LogP -0.76 at pH7.4
CAS DataBase Reference 504-24-5(CAS DataBase Reference)
EWG's Food Scores
FDA UNII
ATC code
NIST Chemistry Reference
EPA Substance Registry System
Pesticides Freedom of Information Act (FOIA)

SAFETY

Risk and Safety Statements

Symbol(GHS)  trực tiếp đá gà hôm nayLiên kết đăng nhậptrực tiếp đá gà hôm nayLiên kết đăng nhậptrực tiếp đá gà hôm nayLiên kết đăng nhập
GHS05,GHS06,GHS09
Signal word  Danger
Hazard statements  H300-H311+H331-H314-H411
Precautionary statements  P260-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  T+,N,T,Xi
Risk Statements  28-36/37/38-51/53-23/24/25
Safety Statements  26-36/37/39-45-60-61-37/39-28A-1
RIDADR  UN 2671 6.1/PG 2
WGK Germany  3
RTECS  US1750000
8-21
Autoignition Temperature 640 °C
Hazard Note  Toxic/Irritant
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  29333999
Toxicity LD50 orally in Rabbit: 21 mg/kg
NFPA 704
1
3 0

4-Aminopyridine price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 275875 4-Aminopyridine ≥99% 504-24-5 1g $35.8 2024-06-20 Buy
Sigma-Aldrich 8.01111 4-Aminopyridine for synthesis 504-24-5 25g $136 2024-06-20 Buy
Sigma-Aldrich 8.01111 4-Aminopyridine for synthesis 504-24-5 10g $68.3 2024-01-07 Buy
Sigma-Aldrich 1162454 Dalfampridine United States Pharmacopeia (USP) Reference Standard 504-24-5 200mg $400 2023-05-15 Buy
TCI Chemical A0414 4-Aminopyridine >99.0%(GC)(T) 504-24-5 25g $30 2024-06-20 Buy
Product number Packaging Price Buy
275875 1g $35.8 Buy
8.01111 25g $136 Buy
8.01111 10g $68.3 Buy
1162454 200mg $400 Buy
A0414 25g $30 Buy

4-Aminopyridine Chemical Properties,Uses,Production

Description

4-Aminopyridine (4-AP, fampridine, dalfampridine) is the first drug approved by the FDA to improve walking in patients with multiple sclerosis (MS). Dalfampridine is a voltage-gated potassium channel blocker that readily penetrates the CNS and increases the conduction and duration of action potential across nerve fibers resulting in enhanced functionality as observed in the walking speed of MS patients.
From a safety perspective, seizure was the most important adverse event from various dalfampridine clinical trials. Therefore, dalfampridine is contraindicated in patients with a history of seizures. Since dalfampridine is primarily excreted by the kidney as unchanged drug, it is also contraindicated in patients with moderate to severe renal impairment. Assessing the overall benefit–risk profile from various clinical trials, the FDA approved dalfampridine (daily oral dose of 10 mg, b.i.d.) to improve walking in MS patients with existing gait impairment.

Chemical Properties

4-aminopyridine is a white crystalline solid that contains about 98% active ingredient. It is soluble in water and slightly soluble in benzene and ether. 4-Aminopyridine formulations are classifi ed by the US Environmental Protection Agency (US EPA) as restricted use pesticides (RUPs) and therefore should be purchased and used only by certifi ed and trained workers and applicators. Avitrol is available as grain baits or as a powder concentrate. It is one of the most prominent avicides. It is registered with the EPA for use against red-winged blackbirds, blackbirds in agricultural fi elds, grackles, pigeons, and sparrows around public buildings, and various birds around livestock feeding pens. Avitrol repels birds by poisoning a few members of a fl ock, causing them to become hyperactive.

Originator

Rush University Medical Center (United States)

Uses

Avitrol (4-aminopyridine), has repellent–toxicant properties for birds and is classed as a severe poison and irritant. This secondary bird repellent can be used as a broadcast bait, causing uncoordinated flight and distress calls and escape responses in nearby birds.

Uses

Dalfampridine is used in characterizing subtypes of potassium channel, and has also been used to manage some of the symptoms of multiple sclerosis, and is indicated for symptomatic improvement of walking in adults with several variations of the disease. Dalfampridine is a precursor to the drug Pinacidil.

Definition

ChEBI: 4-aminopyridine is an aromatic amine that is pyridine bearing a single amino substituent at position 4. An orphan drug in the US, it is used to improve walking in adults with multiple sclerosis. It has a role as an avicide, a potassium channel blocker and an orphan drug. It is an aromatic amine and an aminopyridine.

brand name

Neurelan (E′lan);Ampyra.

Synthesis Reference(s)

Tetrahedron Letters, 39, p. 1313, 1998 DOI:

General Description

White crystalline material with no odor. Used as an avicide, an intermediate and as a fixer for some textile dyes.

Reactivity Profile

4-Aminopyridine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable ga寻找游戏引擎优化系统us hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

4-Aminopyridine, a pyridine compound, is an extremely effective bird poison. In agriculture, 4-AP is used as an extremely effective bird poison sold under the brand name Avitrol. It is highly toxic to all mammals including humans if dosages are exceeded, and as an experimental drug, the recommended dose data is unavailable.

Fire Hazard

Material may produce irritating or poisonous gases in fire. Runoff from fire control water may give off irritating or poisonous gases.

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: hallucinations and vomiting. When heated to decomposition it emits toxic fumes of NOx,.

Potential Exposure

Used as a chemical intermediate in pharmaceuticals; as an agricultural chemical for field crops; and as a bird repellent and poison

in vitro

4-ap acts by selectively blocking fast, voltage-gated k+ channels in excitable tissues. in axons, k+ channel blockade increases the safety factor1 across demyelinated internodes and 4-ap can, therefore, restore conduction in focally demyelinated axons. 4-ap also increases calcium (ca2+) influx at presynaptic terminals thereby enabling an enhancement of neuroneuronal or neuromuscular transmission in normally myelinated neurons [1].

in vivo

investigations of the effects of 4-ap on neurologic deficits in animal in vivo models of demyelinating disease or sci have yielded inconsistent results. some trials have shown indications of potential neurological benefit, such as enhanced motor evoked potentials or reflex activity, while others have yielded no evident gains in function [1].

IC 50

170 and 230 μm at kv1.1 and kv1.2, respectively

storage

Room temperature

Shipping

UN2671 Aminopyridines, Hazard Class: 6.1; Labels: 6.1-Poisonous materials

Purification Methods

Crystallise the aminopyridine from *benzene/EtOH, then recrystallise it twice from water, then crush and dry it for 4hours at 105o [Bates & Hetzer J Res Nat Bur Stand 64A 427 1960]. It has also been crystallised from EtOH, *benzene, *benzene/pet ether, toluene and sublimes in a vacuum. [Beilstein 22/9 V 106.]

Toxicity evaluation

4-Aminopyridine is highly toxic to animals, with an approximate oral LD50 of 3.7 mg/kg body weight in the dog. 4-Aminopyridine blocks potassium channels, resulting in increased cholinergic nervous system activity. The ability of 4-aminopyridine to block potassium channels has led to some speculation that it may be an effective therapy for multiple sclerosis. Clinical signs in poisoned animals often develop within several hours of ingestion and commonly include tachycardia, salivation, tremors, ataxia, and seizures. Death from respiratory failure may develop within 4 hours of exposure. Chemical analysis of frozen stomach contents, liver, and urine is available at some diagnostic laboratories, and residues can be detected in poisoned birds. Although no specifi c antidotal therapy exists, anticonvulsants and activated charcoal administration are recommended.

Incompatibilities

Sodium nitrite, strong oxidizers. Avoid contact with acid anhydrides, acid chlorides; and strong acids.

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposalIncineration with nitrogen oxides removal from effluent gas.

References

[1] hayes kc. the use of 4-aminopyridine (fampridine) in demyelinating disorders. cns drug rev. 2004 winter;10(4):295-316.
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View Lastest Price from 4-Aminopyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
trực tiếp đá gà hôm nayLiên kết đăng nhập 2025-01-24 4-Aminopyridine
504-24-5
US $5.00 / kg 1kg ≥99% 50mt/year Jinan Finer Chemical Co., Ltd
trực tiếp đá gà hôm nayLiên kết đăng nhập 2024-09-06 4-Aminopyridine
504-24-5
US $40.00-40.00 / kg 1kg 0.99 10 tons Hebei Yanxi Chemical Co., Ltd.
trực tiếp đá gà hôm nayLiên kết đăng nhập 2024-09-06 4-Aminopyridine
504-24-5
US $0.00-0.00 / KG 1KG 99% 500000kg Hebei Guanlang Biotechnology Co., Ltd.
  • trực tiếp đá gà hôm nayLiên kết đăng nhập
  • 4-Aminopyridine
    504-24-5
  • US $40.00-40.00 / kg
  • 0.99
  • Hebei Yanxi Chemical Co., Ltd.
  • trực tiếp đá gà hôm nayLiên kết đăng nhập
  • 4-Aminopyridine
    504-24-5
  • US $0.00-0.00 / KG
  • 99%
  • Hebei Guanlang Biotechnology Co., Ltd.
4-AMINOPYRIDINE,REAGENT AMINOPYRIDINE, 4-(P) PARA-AMINOPYRIDINE 4-AMINO PYRIDINE PYRIDIN-4-YLAMINE Phillips 1861 phillips1861 Pimadin (free base) Prc 1237 Pyridine, 4-amino- pyridine,4-amino- pyridine,4-amino-0 pyridine,4-amino-000 Rcra waste number P008 VMI 10-3 vmi10-3 p-Amino Pyridine 4-Amino Pyridine 4-Aminopyridine (RTC is agent for this item in Europe) 4-AMINOPYRIDINE PESTANAL 4-AMINOPYRIDINE INDUCES DEPOLARIZATIO 4-AMINOPYRIDINE, 99+% 4-AMINO PYRIDINE FOR SYNTHESIS 4-Aminopyridine4-AP 4-Pyridinamine, 4-Pyridylamine, Fampridine AMINOPYRIDINE, 4-(RG) Fampridine, pharma grade 4-Aminopyridine(Toxic) 4-Aminopyridine,4-Pyridinamine, 4-Pyridylamine, Fampridine 4-Aminopyridine 1g [504-24-5] 4-Aminopyridine 4-amino-pyridin 4APY Avitrol 200 avitrol200 Compound 1861 Frampridine mi-w-3 TIMTEC-BB SBB004393 AMINOPYRIDINE, 4- AKOS 91150 γ-Pyridylamine PYRIDIN-4-YLAMINE P-AMINO PYRIDINE 4-Aminopyridine;4-AP; Pyridin-4-amine GAMMA-AMINOPYRIDINE GAMMA-PYRIDYLAMINE avitrol AVITROL(R) AURORA KA-676 4-PyridinylaMine EL 970 Neurelan NSC 15041 Pyridine-4-ylaMine faMpridine-SR DalfaMpridine (4-AMinopyridine) Fampridine (4-Aminopyridine) 4-Aminoprridine Dalfampridine/Fampridine
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