ChemicalBook >> CAS DataBase List >>4-Fluoroaniline
4-Fluoroaniline
- CAS No.
- 371-40-4
- Chemical Name:
- 4-Fluoroaniline
- Synonyms
- P-FLUOROANILINE;fluoroanilines;4-fluorobenzenamine;1-AMINO-4-FLUOROBENZENE;NSC 579;uoroaniL;AKOS 91149;4-Fluoranilin;4-fluoro-anilin;p-fluoro-anilin
- CBNumber:
- CB8143013
- Molecular Formula:
- C6H6FN
- Molecular Weight:
- 111.12
- MDL Number:
- MFCD00007829
- MOL File:
- 371-40-4.mol
Last updated:2024-09-01 17:37:15
Melting point | -1.9 °C |
---|---|
Boiling point | 187 °C/767 mmHg (lit.) |
Density | 1.173 g/mL at 25 °C (lit.) |
refractive index |
n |
Flash point | 165 °F |
storage temp. | 2-8°C |
solubility | 33g/l |
pka | 4.65(at 25℃) |
form | Oily Liquid |
color | Clear pale yellow to red-brown |
Specific Gravity | 1.173 |
Water Solubility | 33 g/L (20 ºC) |
Merck | 14,4169 |
BRN | 742030 |
Stability | Stable. Incompatible with acids, oxidizing agents. |
CAS DataBase Reference | 371-40-4(CAS DataBase Reference) |
EWG's Food Scores | |
FDA UNII | |
NIST Chemistry Reference | |
EPA Substance Registry System |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS05,GHS07,GHS08,GHS09 |
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Signal word | Danger | |||||||||
Hazard statements | H302-H314-H373-H410 | |||||||||
Precautionary statements | P273-P280-P301+P312-P303+P361+P353-P305+P351+P338-P314 | |||||||||
Hazard Codes | C,T,Xi,Xn | |||||||||
Risk Statements | 22-34-36/38-33-23/24/25 | |||||||||
Safety Statements | 26-36/37/39-45-37/39-28 | |||||||||
RIDADR | UN 2941 6.1/PG 3 | |||||||||
WGK Germany | 1 | |||||||||
RTECS | BY1575000 | |||||||||
Hazard Note | Toxic/Irritant | |||||||||
TSCA | T | |||||||||
HazardClass | 6.1 | |||||||||
PackingGroup | III | |||||||||
HS Code | 29214210 | |||||||||
NFPA 704 |
|
4-Fluoroaniline price More Price(32)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | F3800 | 4-Fluoroaniline 99% | 371-40-4 | 25g | $24.1 | 2025-03-01 | Buy |
TCI Chemical | F0033 | 4-Fluoroaniline >98.0%(GC)(T) | 371-40-4 | 25mL | $50 | 2025-03-01 | Buy |
TCI Chemical | F0033 | 4-Fluoroaniline >98.0%(GC)(T) | 371-40-4 | 500mL | $528 | 2022-12-16 | Buy |
Alfa Aesar | A15597 | 4-Fluoroaniline, 99% | 371-40-4 | 25g | $24 | 2025-03-01 | Buy |
Alfa Aesar | A15597 | 4-Fluoroaniline, 99% | 371-40-4 | 100g | $43.1 | 2025-03-01 | Buy |
4-Fluoroaniline Chemical Properties,Uses,Production
Chemical Properties
4-Fluoroaniline is a light yellow to gold-coloured liquid.It is easy to oxidize and turn red in air.Uses
4-Fluoroaniline is a degradation product of Ezetimibe (E975000). 4-Fluoroaniline is used as an analytical reagent in the enzymic detection of glucose.Uses
4-Fluoroaniline may be employed as one of the target pollutant during the investigation of biodegradability of fluorinated compounds under aerobic conditions. It may be used for the synthesis of luminescent and cationic monocyclometalated gold(III) monoaryl complexes.Uses
Intermediate in the manufacture of herbicides and plant growth regulators.Preparation
The better process in the one-step process is the nitrobenzene method, which is obtained by deoxygenation, hydrogenation and fluorination. With PdCl2-V2O5 as the catalyst and carbon monoxide as the reducing agent, the reaction was carried out at 160°C for 3h, and the yield of 4-fluoroaniline could reach 90%, with another 10% of aniline as a by-product. With PtO2 as the catalyst, BF3-HF as the fluorinating agent and hydrogen as the reducing agent, the reaction was carried out at 42℃ for 12.5h, with 100% conversion and 95% yield.Definition
ChEBI: 4-fluoroaniline is a primary arylamine that is the derivative of aniline in which the hydrogen at position 4 has been substituted by fluorine. It is used as an intermediate in the manufacture of pharmaceuticals, herbicides and plant growth regulators. It is a primary arylamine and a fluoroaniline.Synthesis Reference(s)
Journal of the American Chemical Society, 70, p. 654, 1948 DOI:
The Journal of Organic Chemistry, 26, p. 4014, 1961 DOI:
General Description
4-fluoroaniline is a light-colored oily liquid. Mixture of three isomers. Insoluble in water and denser than water. Contact may cause irritation to skin, eyes, and mucous membranes. May be toxic by ingestion. Used to make other chemicals. The barriers to inversion and internal rotation of the NH2 group in 4-fluoroaniline has been investigated by far infrared gas spectra.Hazard
Toxic material.Flammability and Explosibility
Not classifiedSafety Profile
Poison by ingestion. Mutation data reported. A severe skin and eye irritant. When heated to decomposition it emits very toxic fumes of NOx and F-.4-Fluoroaniline Preparation Products And Raw materials
Raw materials
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Preparation Products
6-Fluoro-4-(trifluoromethyl)quinolin-2-amine ,97%
2-Hydroxy-4-(trifluoromethyl)quinoline
1-FLUORO-4-(TRIFLUOROMETHYLTHIO)BENZENE
2-BROMO-6-METHYL-4-NITROANILINE
N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline
4-BROMO-6-FLUORO-2-(TRIFLUOROMETHYL)QUINOLINE
4-(Trifluoromethyl)quinoline-2-carbohydrazide ,97%
(6-Fluoro-4-(trifluoromethyl)quinolin-2-yl)methanol ,97%
Ethyl 6-fluoro-4-(trifluoromethyl)quinoline-2-carboxylate ,97%
4-FLUORO-N-METHYLANILINE
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Global( 464)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Siyang Liaoning Biochemical Products Co. Ltd | +8615221114306 | 2594582574@qq.com | China | 574 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12455 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 811 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21698 | 55 |
Fluoropharm Co., Ltd. | +86-0571-85586753; +8613336034509 | sales@fluoropharm.com | China | 1290 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 | sales@nbinno.com | CHINA | 925 | 58 |
Wuhan Boyuan Import & Export Co., LTD | +8615175982296 | Mike@whby-chem.com | China | 980 | 58 |
View Lastest Price from 4-Fluoroaniline manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2025-04-07 | 4-Fluoroaniline
371-40-4
|
US $0.00 / KG | 1KG | ≥99% | 200mt | Jinan Finer Chemical Co., Ltd | ||
2025-01-08 | 4-Fluoroaniline
371-40-4
|
US $10.00 / mL | 1mL | 99% | 5000L | Wuhan Boyuan Import & Export Co., LTD | ||
2024-09-01 | 4-Fluoroaniline
371-40-4
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
- 4-Fluoroaniline
371-40-4
- US $0.00 / KG
- ≥99%
- Jinan Finer Chemical Co., Ltd
- 4-Fluoroaniline
371-40-4
- US $10.00 / mL
- 99%
- Wuhan Boyuan Import & Export Co., LTD
- 4-Fluoroaniline
371-40-4
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
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4-Fluoroaniline>
371-40-4 4-Fluoroaniline
4-Fluoroaniline 371-40-4
uoroaniL
fluoroanilines
4-fluorobenzenamine
1-AMINO-4-FLUOROBENZENE
P-FLUOROANILINE
4-Fluoroaniline, ≥ 98.0%
371-40-4
C6H4FNH2
C2 to C6
Building Blocks
Amines
Organic Building Blocks
Nitrogen Compounds
Fluorobenzene
Amines
Aromatics