ChemicalBook >> CAS DataBase List >>1-Methylimidazole
1-Methylimidazole
- CAS No.
- 616-47-7
- Chemical Name:
- 1-Methylimidazole
- Synonyms
- N-METHYLIMIDAZOLE;1-methyl-1h-imidazole;MIM;MeIm;methyl imidazole;1H-Imidazole, 1-methyl-;N-methylimidazole (1-methylimidazole);1-methylmidazole;N-methyl midazole;N-methyl glyoxaline
- CBNumber:
- CB1316726
- Molecular Formula:
- C4H6N2
- Molecular Weight:
- 82.1
- MDL Number:
- MFCD00005292
- MOL File:
- 616-47-7.mol
- MSDS File:
- SDS
Last updated:2025-03-21 17:31:59
Melting point | −60 °C(lit.) |
---|---|
Boiling point | 198 °C(lit.) |
Density | 1.03 g/mL at 25 °C(lit.) |
vapor pressure | 0.4 mm Hg ( 20 °C) |
refractive index |
n |
Flash point | 198 °F |
storage temp. | Store below +30°C. |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Liquid |
pka | 6.95(at 25℃) |
Specific Gravity | 1.031 |
color | Clear colorless to yellow |
PH | 9.5-10.5 (50g/l, H2O, 20℃) |
PH Range | 9.5 - 11.5 at 100 g/l at 20 °C |
explosive limit | 2.7-15.7%(V) |
Water Solubility | Miscible with water. |
Sensitive | Hygroscopic |
BRN | 105197 |
Stability | Stable, but moisture sensitive. Incompatible with acids, acid anhydrides, strong oxidizing agents, moisture, carbon dioxide, acid chlorides. |
InChIKey | MCTWTZJPVLRJOU-UHFFFAOYSA-N |
LogP | -0.19 at 25℃ |
CAS DataBase Reference | 616-47-7(CAS DataBase Reference) |
EWG's Food Scores | |
FDA UNII | |
NIST Chemistry Reference | |
EPA Substance Registry System |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS05,GHS06 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H302-H311-H314 | |||||||||
Precautionary statements | P270-P280-P301+P312-P301+P330+P331-P303+P361+P353-P305+P351+P338 | |||||||||
Hazard Codes | C,Xn,F,T | |||||||||
Risk Statements | 21/22-34-19-11-20/21/22-52/53-24-22-40-37-21 | |||||||||
Safety Statements | 26-36-45-1/2-36/37/39-16-33-29-61 | |||||||||
RIDADR | UN 3267 8/PG 2 | |||||||||
WGK Germany | 1 | |||||||||
RTECS | NI7000000 | |||||||||
F | 3-10 | |||||||||
Autoignition Temperature | 977 °F | |||||||||
TSCA | Yes | |||||||||
HazardClass | 8 | |||||||||
PackingGroup | III | |||||||||
HS Code | 29332990 | |||||||||
Toxicity | LD50 orally in Rabbit: 1144 mg/kg LD50 dermal Rabbit > 400 - < 640 mg/kg | |||||||||
NFPA 704 |
|
1-Methylimidazole price More Price(49)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | MX1123 | 1-Methylimidazole | 616-47-7 | 4L | $1120 | 2025-03-01 | Buy |
Sigma-Aldrich | 8.05852 | 1-Methylimidazole for synthesis | 616-47-7 | 100mL | $64.5 | 2025-03-01 | Buy |
Sigma-Aldrich | 8.05852 | 1-Methylimidazole for synthesis | 616-47-7 | 1L | $404 | 2025-03-01 | Buy |
Sigma-Aldrich | 336092 | 1-Methylimidazole ≥99%, purified by redistillation | 616-47-7 | 1l | $395 | 2025-03-01 | Buy |
Sigma-Aldrich | 336092 | 1-Methylimidazole ≥99%, purified by redistillation | 616-47-7 | 2l | $584 | 2025-03-01 | Buy |
1-Methylimidazole Chemical Properties,Uses,Production
Chemical Properties
1-Methylimidazole or N-methylimidazole is an aromatic heterocyclic organic compound with the formula CH3C3H3N2. It is a colorless to yellow liquid, with an amine-like odor. It is miscible with water. N-methylimidazole is an important raw material for the synthesis of pharmaceutical intermediates, used in the preparation of losartan, nizofenone, 1-Methyl-1H-imidazole-5-carbonyl chloride hydrochloride and naphazoline hydrochloride, etc. It is also used as a specialty solvent, a base, and as a precursor to some ionic liquids.Uses
1-Methylimidazole is used as a precursor for the synthesis of pyrrole-imidazole polyamides, ionic liquids such as 1-butyl-3-methylimidazolium hexafluorophosphate. It is actively involved in removing acid during the production of diethoxyphenylphosphine. It is used as an intermediate in organic synthesis.Uses
1-Methylimidazole is an aprotic solvent. It is a derivative of imidazole used in the production of pharmaceuticals, pesticides, ion exchange resins, dye intermediates, textile auxiliaries, photographic chemicals, and corrosion inhibitors. It can also be used as a catalyst for the manufacture of polyurethane and a curing agent for epoxy resins. For example, when 1-methylimidazole is added to an aqueous diethylenetriamine (DETA) solution, high CO2 loading can be achieved through phase separation of the absorbent during CO2 absorption[1].Preparation
1-Methylimidazole is prepared mainly by two routes industrially. The main one is acid-catalysed methylation of imidazole by methanol. The second method involves the Radziszewski reaction from glyoxal, formaldehyde, and a mixture of ammonia and methylamine.
(CHO)2 + CH2O + CH3NH2 + NH3 → H2C2N(NCH3)CH + 3 H2O
The compound can be synthesized on a laboratory scale by methylation of imidazole at the pyridine-like nitrogen and subsequent deprotonation. Similarly, 1-methylimidazole may be synthesized by first deprotonating imidazole to form a sodium salt followed by methylation.
H2C2N(NH)CH + CH3I → [H2C2(NH)(NCH3)CH]I
[H2C2(NH)(NCH3)CH]I + NaOH → H2C2N(NCH3)CH + H2O + NaI
Definition
ChEBI: 1-methyl-1H-imidazole is a 1H-imidazole having a methyl substituent at the N-1 position. It is a metabolite of 1-methyl-2-thioimidazole (methimazole). It inhibits bone resorption.General Description
This product has been enhanced for catalysis. 1-Methylimidazole is a derivative of imidazole that is utilized in the manufacture of such classes of items as pharmaceuticals, pesticides, ion-exchange resins, dye intermediates, textile auxiliaries, photographic chemicals, and corrosion inhibitors. It is also used as a catalyst for manufacturing polyurethanes and a curing agent for epoxy resins.Flammability and Explosibility
Not classifiedPurification Methods
Dry it with sodium metal and then distil it. Store it at 0o under dry argon. The picrate has m 159.5-160.5o (from H2O). [Beilstein 23 III/IV 568.]References
[1] You J, et al. Effect of 1-Methylimidazole on CO2 Absorption by Diethylenetriamine (DETA) Aqueous Solutions. Chemical Engineering & Technology, 2017; 40: 2238-2242.1-Methylimidazole Preparation Products And Raw materials
Raw materials
Preparation Products
1-Ethyl-3-methylimidazolium tetrafluoroborate
1-Methyl-2-imidazolecarboxaldehyde
1-METHYL-1H-IMIDAZOLE-2-CARBONYL CHLORIDE,97%
1-Butyl-3-methylimidazolium tetrafluoroborate
Naphazoline hydrochloride
ETHYL 1-METHYL-1H-IMIDAZOLE-2-CARBOXYLATE
1-ETHYL-3-METHYLIMIDAZOLIUM DICYANAMIDE
Chlorpyrifos
Nizofenone
1-Butyl-3-methylimidazolium bromide
1of4
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View Lastest Price from 1-Methylimidazole manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2025-04-11 | 1-Methylimidazole
616-47-7
|
US $0.00 / Kg/Drum | 1KG | 99% | 500mg/year | Jinan Finer Chemical Co., Ltd | ||
2025-03-21 | 1-Methylimidazole
616-47-7
|
US $0.00 / kg | 25kg | 99% | 200MT/MONTH | Hebei Yanxi Chemical Co., Ltd. | ||
2025-03-21 | 1-Methylimidazole
616-47-7
|
US $0.00-0.00 / kg | 1kg | 99% | 2000kgs | Hebei Yanxi Chemical Co., Ltd. |
- 1-Methylimidazole
616-47-7
- US $0.00 / Kg/Drum
- 99%
- Jinan Finer Chemical Co., Ltd
- 1-Methylimidazole
616-47-7
- US $0.00 / kg
- 99%
- Hebei Yanxi Chemical Co., Ltd.
- 1-Methylimidazole
616-47-7
- US $0.00-0.00 / kg
- 99%
- Hebei Yanxi Chemical Co., Ltd.
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1-Methylimidazole>
N-methylimidazole (1-methylimidazole)
N-methyl midazole
N-methyl glyoxaline
1H-Imidazole, 1-methyl-
MIM
1-methyl-1h-imidazole
methyl imidazole
N-METHYLIMIDAZOLE
1-methyl-1h-imidazol
1-methylmidazole
MeIm
1-Methylimidazole (1-MI)
1-Methylimidazole MIm