Identification | Back Directory | [Name]
SU 5205 | [CAS]
3476-86-6 | [Synonyms]
SU 5205 SU 5205; SU-5205; SU5205 2H-Indol-2-one, 3-[(4-fluorophenyl)methylene]-1,3-dihydro- | [Molecular Formula]
C15H10FNO | [MOL File]
3476-86-6.mol | [Molecular Weight]
239.24 |
Chemical Properties | Back Directory | [Melting point ]
194-196 °C | [Boiling point ]
435.3±45.0 °C(Predicted) | [density ]
1.306±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: 5 mg/ml | [form ]
A crystalline solid | [pka]
12.69±0.20(Predicted) |
Hazard Information | Back Directory | [Biological Activity]
SU5205 is an inhibitor of VEGF receptor 2 (VEGFR2/FLK-1) with IC50 of 9.6 μM. | [in vitro]
SU5205 inhibits ligand-induced endothelial mitogenesis for VEGF with an IC 50 of 5.1 μM. | [target]
Target | Value | VEGFR2 (Cell-free assay) | 9.6 μM |
| [storage]
Store at -20°C |
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